CHROMOSOME PULVERIZATION IN CHINESE HAMSTER MULTINUCLEATE CELLS INDUCED BY BLEOMYCIN AND CYTOCHALASIN B
نویسندگان
چکیده
منابع مشابه
Asynchrony of Nuclear Development in Cytochalasin-induced Multinucleate Cells
Synchrony of mitotic nuclei within a multinucleate cell is more of a biological rule than an exception (13) . Synchronized division of nuclei in multinucleate cells has been reported in slime molds (10), protozoa (12, 15, 16), insects (18), and mammalian germ and somatic cells (2, 6, 7, 13) . The influence of a cytoplasmic humoral factor which controls nuclear division has been supported by obs...
متن کاملChromosome Pulverization in Micronuclei Induced by Tritiated Thymidine
Cultures of a pseudodiploid cell line (Don) of Chinese hamster origin were exposed to varying doses of tritiated thymidine (TdR-(3)H) for relatively long periods of time. In addition to previously observed chromosomal aberrations) such as breaks and reunions, a substantial number of interphasic cells with micronuclei and of metaphases associated with pulverized chromosomes was found; both pheno...
متن کاملPropranolol induced chromosomal aberrations in Chinese hamster ovary cell line
Propranolol (PL), a non-selective beta-blocker, is a cardiovascular drug widely used to treat hypertension. The present study was concerned with assessing the cytogenetic effects of this drug on Chinese hamster ovary (CHO) cell line. MTT assay was then carried out to determine the cytotoxicity index (IC50) of the drug. The IC50 value of PL was 0.43±0.02 mM. To investigate the clastogenic effect...
متن کاملEvaluation of chromosome aberrations induced by digoxin in Chinese hamster ovary cells
Digoxin is a cardiac glycoside that has been reported to inhibit growth of multiple tumor cell types in vitro. The present study was assessing the cytogenetic effects of this drug on Chinese Hamster Ovary (CHO) cells. All experiments were performed in triplicate. The IC50 was 22.5 ± 0.8 µg/ml. To investigate the clastogenic effects of drug, chromosomal aberration in metaphase cells were analyze...
متن کاملUsing transient transfected Chinese hamster ovary (CHO) cells by pET28a-LIC-NTF4 in gene therapy
Introduction: Neurotrophins, as a family of proteins, are responsible for induction of the survival, development, and function of neurons. Also, neurotropic factors are growth factors like Neurotrophins that help neurons survive. Moreover, Neurotrophins differentiate between progenitor cells so that neurons are formed. Despite the fact that the majority of mammalian brain neurons are produced p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Japanese Journal of Genetics
سال: 1973
ISSN: 0021-504X,1880-5787
DOI: 10.1266/jjg.48.391